How Children with ASD Develop ADHD Over Time: An Integrated Analysis Through the Lenses of Functional Genomics, Stem Cells, Brain Imaging, and Neurobehavior

Funding Source: National Institutes of Health, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50 HD 105353)

Center Principal Investigator: Qiang Chang
Research Principal Investigators: James Li and Brittany Travers
Co-Investigators: Qiongshi Lu, Diafeng Wang, and Xinyu Zhao

Autism spectrum disorder (ASD) frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD). The negative impact of this co-occurrence on the individual is substantial. We propose to employ state-of-the-art behavioral and neuroimaging, molecular/cellular, genetic/genomic, and machine learning techniques to rigorously and comprehensively characterize the development of ASD and co-occurring ADHD in children and to identify the underlying mechanisms.