Research Epigenetics, Weathering, Aging, and Residential Disadvantage (REWARD)

Funding Source: National Institutes of Health, National Institute on Aging (R01 AG 061080)

Principal Investigators: Kristen Malecki and Michael Engelman
Co-Investigators: Katherine Curtis, Corinne Engelman, and Qiongshi Lu

This project aims to examine patterns of DNA methylation, a key epigenetic mechanism that influences gene expression during development and throughout life in response to environmental and social conditions. Specifically, it examines whether and how personal and neighborhood-level disadvantages impact methylation patterns associated with accelerated biological aging and inflammation, and chronic cardiovascular and metabolic disease outcomes.